A new public beta of DEVONthink is available today. The website includes some very helpful screenshots details that really show that this is a major update. The more modern UI is a big plus, but I'm mostly looking forward to the ability to have multiple databases open at the same time.
For more about how I used DEVONthink in my home office, see My Paperless Office.
I'll have more thoughts on the new version of DEVONthink once I've had a chance to try it out.